Embodied decision making

Decisions as choices between available motor actions

Causal manipulation of persistent activity 

Using chemogenetic & pharmacological methods

Feedback & context encoding

Feedback influences basic contextual effects like surround suppression

Natural image processing in V1

Specific image related information is fed back to V1 from downstream areas

Embodied decision making

In the parietal association cortex, neurons that are involved in planning the motor action needed to report a decision reflect evolving decision processes.  Thus perceptual decision making is implemented in the brain as a process of choosing between available motor actions rather than as a process of representing the properties of the sensory stimulus. 

Shushruth S, Zylberberg A & Shadlen MN. Current Biology (2022)
Shushruth S*, Mazurek M* & Shadlen MN. Journal of Neuroscience (2018)

Causal manipulation of persistent activity

Neurons in association cortex have the ability to maintain persistently elevated activity in the absence of any sensory stimulation. This persistent activity can support many complex computations, like accumulating evidence over time to form a decision. We are using chemogenetic and pharmacological approaches to causally manipulate persistent activity. 

Jeurissen D*, Shushruth S*, et al.  Neuron (2022) 
Shushruth S. Journal of Neuroscience (2015) 

Role of feedback in context encoding in V1 and V2

In primary and secondary visual cortex (V1 and V2), surround suppression has complex properties that depend on feedback from downstream visual areas.

Shushruth S, et al., Journal of Neuroscience (2012)
Shushruth S*, Ichida JM*, et al., Journal of Neurophysiology (2009)

The feedback dependent surround suppression has similar properties in humans and monkeys.
Shushruth S*, Nurminen L*, et al., Journal of Neuroscience (2013)

Natural image processing in primary visual cortex (V1)

Feedback from downstream visual areas influences natural image evoked activity in V1.

Seyedhosseini M*, Shushruth S*, et al. Journal of Neurophysiology (2015)


Dept. of Neuroscience
University of Pittsburgh,
Pittsburgh, PA  


Email: shushruth @ pitt.edu
Phone: +1 (412) 268 4486                    

Mailing address

CNBC 115 I
440 Fifth Ave,
Pittsburgh PA 15213

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